Corso di Laurea in Tecniche di Laboratorio Biomedico - Cuneo

Prodotti della ricerca

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Prodotti della ricerca selezionati

Marini E, Marino M, Gionfriddo G, Maione F, Pandini M, Oddo D, Giorgis M, Rolando B, Blua F, Gastaldi S, Marchio S, Kovachka S, Spyrakis F, Gianquinto E, Di Nicolantonio F, Bertinaria M. (2022) Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAF(V600E) Protein. Molecules (Basel, Switzerland) 27(23) [DOI  PMID]

Foglizzo V, Cocco E, Marchio S. (2022) Advanced Cellular Models for Preclinical Drug Testing: From 2D Cultures to Organ-on-a-Chip Technology. Cancers 14(15) [DOI  PMID]

Foglizzo V, Marchio S. (2022) Nanoparticles as Physically- and Biochemically-Tuned Drug Formulations for Cancers Therapy. Cancers 14(10) [DOI  PMID]

Massa A, Peraldo-Neia C, Vita F, Varamo C, Basirico M, Raggi C, Bernabei P, Erriquez J, Sarotto I, Leone F, Marchio S, Cavalloni G, Aglietta M. (2022) Paclitaxel Restores Sensitivity to Chemotherapy in Preclinical Models of Multidrug-Resistant Intrahepatic Cholangiocarcinoma. Frontiers in oncology 12 771418 [DOI  PMID]

Foglizzo V, Marchio S. (2021) Bacteriophages as Therapeutic and Diagnostic Vehicles in Cancer. Pharmaceuticals (Basel, Switzerland) 14(2) [DOI  PMID]

Goracci M, Pignochino Y, Marchio S. (2020) Phage Display-Based Nanotechnology Applications in Cancer Immunotherapy. Molecules (Basel, Switzerland) 25(4) [DOI  PMID]

Marchio S, Meloni S, Giacomello A, Casciola CM. (2019) Wetting and recovery of nano-patterned surfaces beyond the classical picture. Nanoscale 11(44) 21458-21470 [DOI  PMID]

Quaglia S, Ferrara F, De Leo L, Ziberna F, Vatta S, Marchio S, Sblattero D, Ventura A, Not T. (2019) A Functional Idiotype/Anti-Idiotype Network Is Active in Genetically Gluten-Intolerant Individuals Negative for Both Celiac Disease-Related Intestinal Damage and Serum Autoantibodies. Journal of immunology (Baltimore, Md. : 1950) 202(4) 1079-1087 [DOI  PMID]

Crane ED, Al-Hashimi AA, Chen J, Lynn EG, Won KD, Lhotak S, Naeim M, Platko K, Lebeau P, Byun JH, Shayegan B, Krepinsky JC, Rayner KJ, Marchio S, Pasqualini R, Arap W, Austin RC. (2018) Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions. JCI insight 3(24) [DOI  PMID]

Chohan MO, Marchio S, Morrison LA, Sidman RL, Cavenee WK, Dejana E, Yonas H, Pasqualini R, Arap W. (2019) Emerging Pharmacologic Targets in Cerebral Cavernous Malformation and Potential Strategies to Alter the Natural History of a Difficult Disease: A Review. JAMA neurology 76(4) 492-500 [DOI  PMID]

Marchio S, Meloni S, Giacomello A, Valeriani C, Casciola CM. (2018) Pressure control in interfacial systems: Atomistic simulations of vapor nucleation. The Journal of chemical physics 148(6) 064706 [DOI  PMID]

Staquicini DI, D'Angelo S, Ferrara F, Karjalainen K, Sharma G, Smith TL, Tarleton CA, Jaalouk DE, Kuniyasu A, Baze WB, Chaffee BK, Hanley PW, Barnhart KF, Koivunen E, Marchio S, Sidman RL, Cortes JE, Kantarjian HM, Arap W, Pasqualini R. (2018) Therapeutic targeting of membrane-associated GRP78 in leukemia and lymphoma: preclinical efficacy in vitro and formal toxicity study of BMTP-78 in rodents and primates. The pharmacogenomics journal 18(3) 436-443 [DOI  PMID]

Al-Hashimi AA, Lebeau P, Majeed F, Polena E, Lhotak S, Collins CAF, Pinthus JH, Gonzalez-Gronow M, Hoogenes J, Pizzo SV, Crowther M, Kapoor A, Rak J, Gyulay G, D'Angelo S, Marchio S, Pasqualini R, Arap W, Shayegan B, Austin RC. (2017) Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor. The Journal of biological chemistry 292(51) 21180-21192 [DOI  PMID]

Teixeira AA, Marchio S, Dias-Neto E, Nunes DN, da Silva IT, Chackerian B, Barry M, Lauer RC, Giordano RJ, Sidman RL, Wheeler CM, Cavenee WK, Pasqualini R, Arap W. (2017) Going viral? Linking the etiology of human prostate cancer to the PCA3 long noncoding RNA and oncogenic viruses. EMBO molecular medicine 9(10) 1327-1330 [DOI  PMID]

Lewis VO, Devarajan E, Cardo-Vila M, Thomas DG, Kleinerman ES, Marchio S, Sidman RL, Pasqualini R, Arap W. (2017) BMTP-11 is active in preclinical models of human osteosarcoma and a candidate targeted drug for clinical translation. Proceedings of the National Academy of Sciences of the United States of America 114(30) 8065-8070 [DOI  PMID]

Staquicini DI, Rangel R, Guzman-Rojas L, Staquicini FI, Dobroff AS, Tarleton CA, Ozbun MA, Kolonin MG, Gelovani JG, Marchio S, Sidman RL, Hajjar KA, Arap W, Pasqualini R. (2017) Intracellular targeting of annexin A2 inhibits tumor cell adhesion, migration, and in vivo grafting. Scientific reports 7(1) 4243 [DOI  PMID]

Kolonin MG, Sergeeva A, Staquicini DI, Smith TL, Tarleton CA, Molldrem JJ, Sidman RL, Marchio S, Pasqualini R, Arap W. (2017) Interaction between Tumor Cell Surface Receptor RAGE and Proteinase 3 Mediates Prostate Cancer Metastasis to Bone. Cancer research 77(12) 3144-3150 [DOI  PMID]

Marchio S, Bansal P, Pasqualini R, Arap W. (2017) An antivascular vaccine to boost self-immunity and strike the tumor. Proceedings of the National Academy of Sciences of the United States of America 114(16) E3164-E3165 [DOI  PMID]

Ferrara F, Staquicini DI, Driessen WHP, D'Angelo S, Dobroff AS, Barry M, Lomo LC, Staquicini FI, Cardo-Vila M, Soghomonyan S, Alauddin MM, Flores LG 2nd, Arap MA, Lauer RC, Mathew P, Efstathiou E, Aparicio AM, Troncoso P, Navone NM, Logothetis CJ, Marchio S, Gelovani JG, Sidman RL, Pasqualini R, Arap W. (2016) Targeted molecular-genetic imaging and ligand-directed therapy in aggressive variant prostate cancer. Proceedings of the National Academy of Sciences of the United States of America 113(45) 12786-12791 [DOI  PMID]

Dobroff AS, D'Angelo S, Eckhardt BL, Ferrara F, Staquicini DI, Cardo-Vila M, Staquicini FI, Nunes DN, Kim K, Driessen WHP, Hajitou A, Lomo LC, Barry M, Krishnamurthy S, Sahin A, Woodward WA, Prossnitz ER, Anderson RL, Dias-Neto E, Brown-Glaberman UA, Royce ME, Ueno NT, Cristofanilli M, Hortobagyi GN, Marchio S, Gelovani JG, Sidman RL, Arap W, Pasqualini R. (2016) Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes. Proceedings of the National Academy of Sciences of the United States of America 113(45) 12780-12785 [DOI  PMID]

Cardo-Vila M, Marchio S, Sato M, Staquicini FI, Smith TL, Bronk JK, Yin G, Zurita AJ, Sun M, Behrens C, Sidman RL, Lee JJ, Hong WK, Wistuba II, Arap W, Pasqualini R. (2016) Interleukin-11 Receptor Is a Candidate Target for Ligand-Directed Therapy in Lung Cancer: Analysis of Clinical Samples and BMTP-11 Preclinical Activity. The American journal of pathology 186(8) 2162-2170 [DOI  PMID]

Marchio S, Sidman RL, Arap W, Pasqualini R. (2016) Brain endothelial cell-targeted gene therapy of neurovascular disorders. EMBO molecular medicine 8(6) 592-4 [DOI  PMID]

Bartolini A, Cardaci S, Lamba S, Oddo D, Marchio C, Cassoni P, Amoreo CA, Corti G, Testori A, Bussolino F, Pasqualini R, Arap W, Cora D, Di Nicolantonio F, Marchio S. (2016) BCAM and LAMA5 Mediate the Recognition between Tumor Cells and the Endothelium in the Metastatic Spreading of KRAS-Mutant Colorectal Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 22(19) 4923-4933 [DOI  PMID]

Dondossola E, Dobroff AS, Marchio S, Cardo-Vila M, Hosoya H, Libutti SK, Corti A, Sidman RL, Arap W, Pasqualini R. (2016) Self-targeting of TNF-releasing cancer cells in preclinical models of primary and metastatic tumors. Proceedings of the National Academy of Sciences of the United States of America 113(8) 2223-8 [DOI  PMID]

Yao VJ, D'Angelo S, Butler KS, Theron C, Smith TL, Marchio S, Gelovani JG, Sidman RL, Dobroff AS, Brinker CJ, Bradbury ARM, Arap W, Pasqualini R. (2016) Ligand-targeted theranostic nanomedicines against cancer. Journal of controlled release : official journal of the Controlled Release Society 240 267-286 [DOI  PMID]

Bartolini A, Di Paolo D, Noghero A, Murgia D, Sementa AR, Cilli M, Pasqualini R, Arap W, Bussolino F, Ponzoni M, Pastorino F, Marchio S. (2015) The Neuronal Pentraxin-2 Pathway Is an Unrecognized Target in Human Neuroblastoma, Which Also Offers Prognostic Value in Patients. Cancer research 75(20) 4265-71 [DOI  PMID]

Cossu I, Bottoni G, Loi M, Emionite L, Bartolini A, Di Paolo D, Brignole C, Piaggio F, Perri P, Sacchi A, Curnis F, Gagliani MC, Bruno S, Marini C, Gori A, Longhi R, Murgia D, Sementa AR, Cilli M, Tacchetti C, Corti A, Sambuceti G, Marchio S, Ponzoni M, Pastorino F. (2015) Neuroblastoma-targeted nanocarriers improve drug delivery and penetration, delay tumor growth and abrogate metastatic diffusion. Biomaterials 68 89-99 [DOI  PMID]

Salameh A, Lee AK, Cardo-Vila M, Nunes DN, Efstathiou E, Staquicini FI, Dobroff AS, Marchio S, Navone NM, Hosoya H, Lauer RC, Wen S, Salmeron CC, Hoang A, Newsham I, Lima LA, Carraro DM, Oliviero S, Kolonin MG, Sidman RL, Do KA, Troncoso P, Logothetis CJ, Brentani RR, Calin GA, Cavenee WK, Dias-Neto E, Pasqualini R, Arap W. (2015) PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3. Proceedings of the National Academy of Sciences of the United States of America 112(27) 8403-8 [DOI  PMID]

Pignochino Y, Dell'Aglio C, Inghilleri S, Zorzetto M, Basirico M, Capozzi F, Canta M, Piloni D, Cemmi F, Sangiolo D, Gammaitoni L, Soster M, Marchio S, Pozzi E, Morbini P, Luisetti M, Aglietta M, Grignani G, Stella GM. (2015) The combination of sorafenib and everolimus shows antitumor activity in preclinical models of malignant pleural mesothelioma. BMC cancer 15 374 [DOI  PMID]

Nunes DN, Dias-Neto E, Cardo-Vila M, Edwards JK, Dobroff AS, Giordano RJ, Mandelin J, Brentani HP, Hasselgren C, Yao VJ, Marchio S, Pereira CA, Passetti F, Calin GA, Sidman RL, Arap W, Pasqualini R. (2015) Synchronous down-modulation of miR-17 family members is an early causative event in the retinal angiogenic switch. Proceedings of the National Academy of Sciences of the United States of America 112(12) 3770-5 [DOI  PMID]

Peraldo-Neia C, Cavalloni G, Soster M, Gammaitoni L, Marchio S, Sassi F, Trusolino L, Bertotti A, Medico E, Capussotti L, Aglietta M, Leone F. (2014) Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models. BMC cancer 14 918 [DOI  PMID]

Parri M, Pietrovito L, Grandi A, Campagnoli S, De Camilli E, Bianchini F, Marchio S, Bussolino F, Jin B, Sarmientos P, Grandi G, Viale G, Pileri P, Chiarugi P, Grifantini R. (2014) Angiopoietin-like 7, a novel pro-angiogenetic factor over-expressed in cancer. Angiogenesis 17(4) 881-96 [DOI  PMID]

Cardaci S, Soster M, Bussolino F, Marchio S. (2013) The V1/V2 loop of HIV-1 gp120 is necessary for Tat binding and consequent modulation of virus entry. FEBS letters 587(18) 2943-51 [DOI  PMID]

Loi M, Di Paolo D, Soster M, Brignole C, Bartolini A, Emionite L, Sun J, Becherini P, Curnis F, Petretto A, Sani M, Gori A, Milanese M, Gambini C, Longhi R, Cilli M, Allen TM, Bussolino F, Arap W, Pasqualini R, Corti A, Ponzoni M, Marchio S, Pastorino F. (2013) Novel phage display-derived neuroblastoma-targeting peptides potentiate the effect of drug nanocarriers in preclinical settings. Journal of controlled release : official journal of the Controlled Release Society 170(2) 233-41 [DOI  PMID]

Graziano S, Marchio S, Bussolino F, Arese M. (2013) A peptide from the extracellular region of the synaptic protein alpha Neurexin stimulates angiogenesis and the vascular specific tyrosine kinase Tie2. Biochemical and biophysical research communications 432(4) 574-9 [DOI  PMID]

Arap W, Pasqualini R, Montalti M, Petrizza L, Prodi L, Rampazzo E, Zaccheroni N, Marchio S. (2013) Luminescent silica nanoparticles for cancer diagnosis. Current medicinal chemistry 20(17) 2195-211 [DOI  PMID]

Pignochino Y, Dell'Aglio C, Basirico M, Capozzi F, Soster M, Marchio S, Bruno S, Gammaitoni L, Sangiolo D, Torchiaro E, D'Ambrosio L, Fagioli F, Ferrari S, Alberghini M, Picci P, Aglietta M, Grignani G. (2013) The Combination of Sorafenib and Everolimus Abrogates mTORC1 and mTORC2 upregulation in osteosarcoma preclinical models. Clinical cancer research : an official journal of the American Association for Cancer Research 19(8) 2117-31 [DOI  PMID]

Marchio S, Astanina E, Bussolino F. (2013) Emerging lymphae for the fountain of life. The EMBO journal 32(5) 609-11 [DOI  PMID]

Marchio S, Soster M, Cardaci S, Muratore A, Bartolini A, Barone V, Ribero D, Monti M, Bovino P, Sun J, Giavazzi R, Asioli S, Cassoni P, Capussotti L, Pucci P, Bugatti A, Rusnati M, Pasqualini R, Arap W, Bussolino F. (2012) A complex of alpha6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6. EMBO molecular medicine 4(11) 1156-75 [DOI  PMID]

Soster M, Juris R, Bonacchi S, Genovese D, Montalti M, Rampazzo E, Zaccheroni N, Garagnani P, Bussolino F, Prodi L, Marchio S. (2012) Targeted dual-color silica nanoparticles provide univocal identification of micrometastases in preclinical models of colorectal cancer. International journal of nanomedicine 7 4797-807 [DOI  PMID]

Napione L, Strasly M, Meda C, Mitola S, Alvaro M, Doronzo G, Marchio S, Giraudo E, Primo L, Arese M, Bussolino F. (2012) IL-12-dependent innate immunity arrests endothelial cells in G0-G1 phase by a p21(Cip1/Waf1)-mediated mechanism. Angiogenesis 15(4) 713-25 [DOI  PMID]

Cavalloni G, Peraldo-Neia C, Sarotto I, Gammaitoni L, Migliardi G, Soster M, Marchio S, Aglietta M, Leone F. (2012) Antitumor activity of Src inhibitor saracatinib (AZD-0530) in preclinical models of biliary tract carcinomas. Molecular cancer therapeutics 11(7) 1528-38 [DOI  PMID]

Loi M, Marchio S, Becherini P, Di Paolo D, Soster M, Curnis F, Brignole C, Pagnan G, Perri P, Caffa I, Longhi R, Nico B, Bussolino F, Gambini C, Ribatti D, Cilli M, Arap W, Pasqualini R, Allen TM, Corti A, Ponzoni M, Pastorino F. (2010) Combined targeting of perivascular and endothelial tumor cells enhances anti-tumor efficacy of liposomal chemotherapy in neuroblastoma. Journal of controlled release : official journal of the Controlled Release Society 145(1) 66-73 [DOI  PMID]

Marchio S, Arap W, Pasqualini R. (2009) Targeting the extracellular signature of metastatic colorectal cancers. Expert opinion on therapeutic targets 13(3) 363-79 [DOI  PMID]

Zanivan S, Cascone I, Peyron C, Molineris I, Marchio S, Caselle M, Bussolino F. (2007) A new computational approach to analyze human protein complexes and predict novel protein interactions. Genome biology 8(12) R256 [DOI  PMID]

Primo L, Ferrandi C, Roca C, Marchio S, di Blasio L, Alessio M, Bussolino F. (2005) Identification of CD36 molecular features required for its in vitro angiostatic activity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19(12) 1713-5 [DOI  PMID]

Marchio S, Alfano M, Primo L, Gramaglia D, Butini L, Gennero L, De Vivo E, Arap W, Giacca M, Pasqualini R, Bussolino F. (2005) Cell surface-associated Tat modulates HIV-1 infection and spreading through a specific interaction with gp120 viral envelope protein. Blood 105(7) 2802-11 [DOI  PMID]

Marchio S, Lahdenranta J, Schlingemann RO, Valdembri D, Wesseling P, Arap MA, Hajitou A, Ozawa MG, Trepel M, Giordano RJ, Nanus DM, Dijkman HB, Oosterwijk E, Sidman RL, Cooper MD, Bussolino F, Pasqualini R, Arap W. (2004) Aminopeptidase A is a functional target in angiogenic blood vessels. Cancer cell 5(2) 151-62 [DOI  PMID]

Marchio S, Primo L, Pagano M, Palestro G, Albini A, Veikkola T, Cascone I, Alitalo K, Bussolino F. (1999) Vascular endothelial growth factor-C stimulates the migration and proliferation of Kaposi's sarcoma cells. The Journal of biological chemistry 274(39) 27617-22 [DOI  PMID]

Marconcini L, Marchio S, Morbidelli L, Cartocci E, Albini A, Ziche M, Bussolino F, Oliviero S. (1999) c-fos-induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro. Proceedings of the National Academy of Sciences of the United States of America 96(17) 9671-6 [DOI  PMID]

Maggiora P, Marchio S, Stella MC, Giai M, Belfiore A, De Bortoli M, Di Renzo MF, Costantino A, Sismondi P, Comoglio PM. (1998) Overexpression of the RON gene in human breast carcinoma. Oncogene 16(22) 2927-33 [DOI  PMID]

Foglizzo V, Cocco E, Marchiò S. (2022) Advanced cellular models for preclinical drug testing: from 2D cultures to organ-on-a-chip technology. Cancers 14(15):3692 [DOI PMID]

Foglizzo V, Marchiò S. (2022) Nanoparticles as physically- and biochemically-tuned drug formulations for cancers therapy. Cancers 14(10):2437 [DOI PMID]

Massa A, Peraldo-Neia C, Vita F, Varamo, C, Basiricò M, Raggi C, Bernabei P, Erriquez J, Sarotto I, Leone F, Marchiò S*, Cavalloni G*, Aglietta M*. (2022) Paclitaxel restores sensitivity to chemotherapy in preclinical models of multidrug-resistant intrahepatic cholangiocarcinoma. Front Oncol 121:771418 [DOI PMID]

Foglizzo V, Marchiò S. (2021) Bacteriophages as therapeutic and diagnostic vehicles in cancer. Pharmaceuticals 14(2) [DOI  PMID]

Goracci M, Pignochino Y, Marchiò S. (2020) Phage display-based nanotechnology applications in cancer immunotherapy. Molecules 25(4) [DOI  PMID]

Quaglia S, Ferrara F, De Leo L, Ziberna F, Vatta S, Marchiò S, Sblattero D, Ventura A, Not T. (2019) A functional idiotype/anti-idiotype network is active in genetically gluten-intolerant individuals negative for both celiac disease-related intestinal damage and serum autoantibodies. Journal of Immunology 202(4) 1079-1087 [DOI  PMID]

Crane ED, Al-Hashimi AA, Chen J, Lynn EG, Won KD, Lhotak S, Naeim M, Platko K, Lebeau P, Byun JH, Shayegan B, Krepinsky JC, Rayner KJ, Marchiò S, Pasqualini R, Arap W, Austin RC. (2018) Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions. JCI Insight 3(24) [DOI  PMID]

Chohan MO*, Marchiò S*, Morrison LA, Sidman RL, Cavenee WK, Dejana E, Yonas H, Pasqualini R, Arap W. (2019) Emerging pharmacologic targets in cerebral cavernous malformation and potential strategies to alter the natural history of a difficult disease: A Review. JAMA Neurology 76(4) 492-500 [DOI  PMID] *co-first

Staquicini DI, D'Angelo S, Ferrara F, Karjalainen K, Sharma G, Smith TL, Tarleton CA, Jaalouk DE, Kuniyasu A, Baze WB, Chaffee BK, Hanley PW, Barnhart KF, Koivunen E, Marchiò S, Sidman RL, Cortes JE, Kantarjian HM, Arap W, Pasqualini R. (2018) Therapeutic targeting of membrane-associated GRP78 in leukemia and lymphoma: preclinical efficacy in vitro and formal toxicity study of BMTP-78 in rodents and primates. The Pharmacogenomics Journal 18(3) 436-443 [DOI  PMID]

Al-Hashimi AA, Lebeau P, Majeed F, Polena E, Lhotak S, Collins CAF, Pinthus JH, Gonzalez-Gronow M, Hoogenes J, Pizzo SV, Crowther M, Kapoor A, Rak J, Gyulay G, D'Angelo S, Marchiò S, Pasqualini R, Arap W, Shayegan B, Austin RC. (2017) Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor. The Journal of Biological Chemistry 292(51) 21180-21192 [DOI  PMID]

Teixeira AA*, Marchiò S*, Dias-Neto E, Nunes DN, da Silva IT, Chackerian B, Barry M, Lauer RC, Giordano RJ, Sidman RL, Wheeler CM, Cavenee WK, Pasqualini R, Arap W. (2017) Going viral? Linking the etiology of human prostate cancer to the PCA3 long noncoding RNA and oncogenic viruses. EMBO Molecular Medicine 9(10) 1327-1330 [DOI  PMID] *co-first

Lewis VO, Devarajan E, Cardo-Vila M, Thomas DG, Kleinerman ES, Marchiò S, Sidman RL, Pasqualini R, Arap W. (2017) BMTP-11 is active in preclinical models of human osteosarcoma and a candidate targeted drug for clinical translation. Proceedings of the National Academy of Sciences of the United States of America 114(30) 8065-8070 [DOI  PMID]

Staquicini DI, Rangel R, Guzman-Rojas L, Staquicini FI, Dobroff AS, Tarleton CA, Ozbun MA, Kolonin MG, Gelovani JG, Marchiò S, Sidman RL, Hajjar KA, Arap W, Pasqualini R. (2017) Intracellular targeting of annexin A2 inhibits tumor cell adhesion, migration, and in vivo grafting. Scientific Reports 7(1) 4243 [DOI  PMID]

Kolonin MG, Sergeeva A, Staquicini DI, Smith TL, Tarleton CA, Molldrem JJ, Sidman RL, Marchiò S, Pasqualini R, Arap W. (2017) Interaction between tumor cell surface receptor RAGE and proteinase 3 mediates prostate cancer metastasis to bone. Cancer Research 77(12) 3144-3150 [DOI  PMID]

Marchiò S, Bansal P, Pasqualini R, Arap W. (2017) An antivascular vaccine to boost self-immunity and strike the tumor. Proceedings of the National Academy of Sciences of the United States of America 114(16) E3164-E3165 [DOI  PMID]

Ferrara F, Staquicini DI, Driessen WHP, D'Angelo S, Dobroff AS, Barry M, Lomo LC, Staquicini FI, Cardo-Vila M, Soghomonyan S, Alauddin MM, Flores LG 2nd, Arap MA, Lauer RC, Mathew P, Efstathiou E, Aparicio AM, Troncoso P, Navone NM, Logothetis CJ, Marchiò S, Gelovani JG, Sidman RL, Pasqualini R, Arap W. (2016) Targeted molecular-genetic imaging and ligand-directed therapy in aggressive variant prostate cancer. Proceedings of the National Academy of Sciences of the United States of America 113(45) 12786-12791 [DOI  PMID]

Dobroff AS, D'Angelo S, Eckhardt BL, Ferrara F, Staquicini DI, Cardo-Vila M, Staquicini FI, Nunes DN, Kim K, Driessen WHP, Hajitou A, Lomo LC, Barry M, Krishnamurthy S, Sahin A, Woodward WA, Prossnitz ER, Anderson RL, Dias-Neto E, Brown-Glaberman UA, Royce ME, Ueno NT, Cristofanilli M, Hortobagyi GN, Marchiò S, Gelovani JG, Sidman RL, Arap W, Pasqualini R. (2016) Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes. Proceedings of the National Academy of Sciences of the United States of America 113(45) 12780-12785 [DOI  PMID]

Cardo-Vila M*, Marchiò S*, Sato M*, Staquicini FI, Smith TL, Bronk JK, Yin G, Zurita AJ, Sun M, Behrens C, Sidman RL, Lee JJ, Hong WK, Wistuba II, Arap W, Pasqualini R. (2016) Interleukin-11 Receptor Is a Candidate Target for Ligand-Directed Therapy in Lung Cancer: Analysis of Clinical Samples and BMTP-11 Preclinical Activity. The American Journal of Pathology 186(8) 2162-2170 [DOI  PMID] *co-first

Marchiò S, Sidman RL, Arap W, Pasqualini R. (2016) Brain endothelial cell-targeted gene therapy of neurovascular disorders. EMBO Molecular Medicine 8(6) 592-4 [DOI  PMID]

Bartolini A, Cardaci S, Lamba S, Oddo D, Marchiò C, Cassoni P, Amoreo CA, Corti G, Testori A, Bussolino F, Pasqualini R, Arap W, Cora D, Di Nicolantonio F, Marchiò S. (2016) BCAM and LAMA5 mediate the recognition between tumor cells and the endothelium in the metastatic spreading of KRAS-mutant colorectal cancer. Clinical Cancer Research 22(19) 4923-4933 [DOI  PMID]

Dondossola E, Dobroff AS, Marchiò S, Cardo-Vila M, Hosoya H, Libutti SK, Corti A, Sidman RL, Arap W, Pasqualini R. (2016) Self-targeting of TNF-releasing cancer cells in preclinical models of primary and metastatic tumors. Proceedings of the National Academy of Sciences of the United States of America 113(8) 2223-8 [DOI  PMID]

Yao VJ, D'Angelo S, Butler KS, Theron C, Smith TL, Marchiò S, Gelovani JG, Sidman RL, Dobroff AS, Brinker CJ, Bradbury ARM, Arap W, Pasqualini R. (2016) Ligand-targeted theranostic nanomedicines against cancer. Journal of Controlled Release 240 267-286 [DOI  PMID]

Bartolini A, Di Paolo D, Noghero A, Murgia D, Sementa AR, Cilli M, Pasqualini R, Arap W, Bussolino F, Ponzoni M, Pastorino F, Marchiò S. (2015) The neuronal pentraxin-2 pathway is an unrecognized target in human neuroblastoma, which also offers prognostic value in patients. Cancer Research 75(20) 4265-71 [DOI  PMID]

Cossu I, Bottoni G, Loi M, Emionite L, Bartolini A, Di Paolo D, Brignole C, Piaggio F, Perri P, Sacchi A, Curnis F, Gagliani MC, Bruno S, Marini C, Gori A, Longhi R, Murgia D, Sementa AR, Cilli M, Tacchetti C, Corti A, Sambuceti G, Marchiò S*, Ponzoni M*, Pastorino F*. (2015) Neuroblastoma-targeted nanocarriers improve drug delivery and penetration, delay tumor growth and abrogate metastatic diffusion. Biomaterials 68 89-99 [DOI  PMID] *co-last

Salameh A, Lee AK, Cardo-Vila M, Nunes DN, Efstathiou E, Staquicini FI, Dobroff AS, Marchiò S, Navone NM, Hosoya H, Lauer RC, Wen S, Salmeron CC, Hoang A, Newsham I, Lima LA, Carraro DM, Oliviero S, Kolonin MG, Sidman RL, Do KA, Troncoso P, Logothetis CJ, Brentani RR, Calin GA, Cavenee WK, Dias-Neto E, Pasqualini R, Arap W. (2015) PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3. Proceedings of the National Academy of Sciences of the United States of America 112(27) 8403-8 [DOI  PMID]

Pignochino Y, Dell'Aglio C, Inghilleri S, Zorzetto M, Basirico M, Capozzi F, Canta M, Piloni D, Cemmi F, Sangiolo D, Gammaitoni L, Soster M, Marchiò S, Pozzi E, Morbini P, Luisetti M, Aglietta M, Grignani G, Stella GM. (2015) The combination of sorafenib and everolimus shows antitumor activity in preclinical models of malignant pleural mesothelioma. BMC Cancer 15 374 [DOI  PMID]

Nunes DN, Dias-Neto E, Cardo-Vila M, Edwards JK, Dobroff AS, Giordano RJ, Mandelin J, Brentani HP, Hasselgren C, Yao VJ, Marchiò S, Pereira CA, Passetti F, Calin GA, Sidman RL, Arap W, Pasqualini R. (2015) Synchronous down-modulation of miR-17 family members is an early causative event in the retinal angiogenic switch. Proceedings of the National Academy of Sciences of the United States of America 112(12) 3770-5 [DOI  PMID]

Peraldo-Neia C, Cavalloni G, Soster M, Gammaitoni L, Marchiò S, Sassi F, Trusolino L, Bertotti A, Medico E, Capussotti L, Aglietta M, Leone F. (2014) Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models. BMC Cancer 14 918 [DOI  PMID]

Parri M, Pietrovito L, Grandi A, Campagnoli S, De Camilli E, Bianchini F, Marchiò S, Bussolino F, Jin B, Sarmientos P, Grandi G, Viale G, Pileri P, Chiarugi P, Grifantini R. (2014) Angiopoietin-like 7, a novel pro-angiogenetic factor over-expressed in cancer. Angiogenesis 17(4) 881-96 [DOI  PMID]

Cardaci S, Soster M, Bussolino F, Marchiò S. (2013) The V1/V2 loop of HIV-1 gp120 is necessary for Tat binding and consequent modulation of virus entry. FEBS Letters 587(18) 2943-51 [DOI  PMID]

Loi M, Di Paolo D, Soster M, Brignole C, Bartolini A, Emionite L, Sun J, Becherini P, Curnis F, Petretto A, Sani M, Gori A, Milanese M, Gambini C, Longhi R, Cilli M, Allen TM, Bussolino F, Arap W, Pasqualini R, Corti A, Ponzoni M, Marchiò S, Pastorino F. (2013) Novel phage display-derived neuroblastoma-targeting peptides potentiate the effect of drug nanocarriers in preclinical settings. Journal of Controlled Release 170(2) 233-41 [DOI  PMID]

Graziano S, Marchiò S, Bussolino F, Arese M. (2013) A peptide from the extracellular region of the synaptic protein alpha Neurexin stimulates angiogenesis and the vascular specific tyrosine kinase Tie2. Biochemical and Biophysical Research Communications 432(4) 574-9 [DOI  PMID]

Arap W, Pasqualini R, Montalti M, Petrizza L, Prodi L, Rampazzo E, Zaccheroni N, Marchiò S. (2013) Luminescent silica nanoparticles for cancer diagnosis. Current Medicinal Chemistry 20(17) 2195-211 [DOI  PMID]

Pignochino Y, Dell'Aglio C, Basirico M, Capozzi F, Soster M, Marchiò S, Bruno S, Gammaitoni L, Sangiolo D, Torchiaro E, D'Ambrosio L, Fagioli F, Ferrari S, Alberghini M, Picci P, Aglietta M, Grignani G. (2013) The combination of Sorafenib and Everolimus abrogates mTORC1 and mTORC2 upregulation in osteosarcoma preclinical models. Clinical Cancer Research 19(8) 2117-31 [DOI  PMID]

Marchiò S, Astanina E, Bussolino F. (2013) Emerging lymphae for the fountain of life. The EMBO Journal 32(5) 609-11 [DOI  PMID]

Marchiò S, Soster M, Cardaci S, Muratore A, Bartolini A, Barone V, Ribero D, Monti M, Bovino P, Sun J, Giavazzi R, Asioli S, Cassoni P, Capussotti L, Pucci P, Bugatti A, Rusnati M, Pasqualini R, Arap W, Bussolino F. (2012) A complex of alpha6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6. EMBO Molecular Medicine 4(11) 1156-75 [DOI  PMID]

Soster M, Juris R, Bonacchi S, Genovese D, Montalti M, Rampazzo E, Zaccheroni N, Garagnani P, Bussolino F, Prodi L, Marchiò S. (2012) Targeted dual-color silica nanoparticles provide univocal identification of micrometastases in preclinical models of colorectal cancer. International Journal of Nanomedicine 7 4797-807 [DOI  PMID]

Napione L, Strasly M, Meda C, Mitola S, Alvaro M, Doronzo G, Marchiò S, Giraudo E, Primo L, Arese M, Bussolino F. (2012) IL-12-dependent innate immunity arrests endothelial cells in G0-G1 phase by a p21(Cip1/Waf1)-mediated mechanism. Angiogenesis 15(4) 713-25 [DOI  PMID]

Cavalloni G, Peraldo-Neia C, Sarotto I, Gammaitoni L, Migliardi G, Soster M, Marchiò S, Aglietta M, Leone F. (2012) Antitumor activity of Src inhibitor saracatinib (AZD-0530) in preclinical models of biliary tract carcinomas. Molecular Cancer Therapeutics 11(7) 1528-38 [DOI  PMID]

Virga A, Rivolo P, Descrovi E, Chiolerio A, Digregorio G, Frascella F, Soster M, Bussolino F, Marchiò S, Geobaldo F, Giorgis F (2012). SERS active Ag nanoparticles in mesoporous silicon: detection of organic molecules and peptide-antibody assays. J Raman Spectroscopy 43:730-736 [DOI]

Loi M, Marchiò S, Becherini P, Di Paolo D, Soster M, Curnis F, Brignole C, Pagnan G, Perri P, Caffa I, Longhi R, Nico B, Bussolino F, Gambini C, Ribatti D, Cilli M, Arap W, Pasqualini R, Allen TM, Corti A, Ponzoni M, Pastorino F. (2010) Combined targeting of perivascular and endothelial tumor cells enhances anti-tumor efficacy of liposomal chemotherapy in neuroblastoma. Journal of Controlled Release 145(1) 66-73 [DOI  PMID]

Marchiò S, Arap W, Pasqualini R. (2009) Targeting the extracellular signature of metastatic colorectal cancers. Expert Opinion on Therapeutic Targets 13(3) 363-79 [DOI  PMID]

Zanivan S, Cascone I, Peyron C, Molineris I, Marchiò S, Caselle M, Bussolino F. (2007) A new computational approach to analyze human protein complexes and predict novel protein interactions. Genome Biology 8(12) R256 [DOI  PMID]

Primo L, Ferrandi C, Roca C, Marchiò S, di Blasio L, Alessio M, Bussolino F. (2005) Identification of CD36 molecular features required for its in vitro angiostatic activity. FASEB Journal 19(12) 1713-5 [DOI  PMID]

Marchiò S, Alfano M, Primo L, Gramaglia D, Butini L, Gennero L, De Vivo E, Arap W, Giacca M, Pasqualini R, Bussolino F. (2005) Cell surface-associated Tat modulates HIV-1 infection and spreading through a specific interaction with gp120 viral envelope protein. Blood 105(7) 2802-11 [DOI  PMID]

Marchiò S, Lahdenranta J, Schlingemann RO, Valdembri D, Wesseling P, Arap MA, Hajitou A, Ozawa MG, Trepel M, Giordano RJ, Nanus DM, Dijkman HB, Oosterwijk E, Sidman RL, Cooper MD, Bussolino F, Pasqualini R, Arap W. (2004) Aminopeptidase A is a functional target in angiogenic blood vessels. Cancer Cell 5(2) 151-62 [DOI  PMID]

Marchiò S, Primo L, Pagano M, Palestro G, Albini A, Veikkola T, Cascone I, Alitalo K, Bussolino F. (1999) Vascular endothelial growth factor-C stimulates the migration and proliferation of Kaposi's sarcoma cells. The Journal of Biological Chemistry 274(39) 27617-22 [DOI  PMID]

Marconcini L, Marchiò S, Morbidelli L, Cartocci E, Albini A, Ziche M, Bussolino F, Oliviero S. (1999) c-fos-induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro. Proceedings of the National Academy of Sciences of the United States of America 96(17) 9671-6 [DOI  PMID]

Maggiora P, Marchiò S, Stella MC, Giai M, Belfiore A, De Bortoli M, Di Renzo MF, Costantino A, Sismondi P, Comoglio PM. (1998) Overexpression of the RON gene in human breast carcinoma. Oncogene 16(22) 2927-33 [DOI  PMID]

Insegnamenti

• Biochemistry, cellular and molecular biology (ONC0251)
  Artificial Intelligence for Biomedicine and Healthcare
• Biochimica (MED3080A)
  Corso di laurea in Igiene Dentale
• Biochimica (Canale C) (SME0980)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• Biochimica metabolica (canale C) (SME0980B)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• Biochimica strutturale (canale C) (SME0980A)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• I. CHIMICA, PROPEDEUTICA BIOCHIMICA E BIOCHIMICA (MED2867)
  Corso di Laurea in Tecniche di Laboratorio Biomedico - Cuneo
• Multi-omics and Data Science for Precision Medicine (ONC0260)
  Artificial Intelligence for Biomedicine and Healthcare
• ONC0251A Structural biochemistry, or the molecules of life (ONC0251A)
  Artificial Intelligence for Biomedicine and Healthcare
• ONC0260B Proteomics (ONC0260B)
  Artificial Intelligence for Biomedicine and Healthcare
• PROPEDEUTICA BIOCHIMICA E BIOCHIMICA (MED2867B)
  Corso di Laurea in Tecniche di Laboratorio Biomedico - Cuneo
• SCIENZE BIOMEDICHE 2 (MED3080)
  Corso di laurea in Igiene Dentale

Temi di ricerca

 

Research main topics

My research group investigates the tumor microenvironment using a phage display-based platform that combines high-throughput screenings, next generation sequencing, and bioinformatics. Through phage display, random peptides or antibodies are produced and selected for affinity towards a substrate of interest (a protein, a cell, a tissue, or an entire organism). This technology helps us identify molecular markers and reconstruct protein-protein interactions. For the past 25 years, we have applied phage display to numerous types of tumors to identify new targets accessible through the bloodstream, and to develop target-specific theranostic nanosystems.

Our AIRC project on FRidA

Attività in agenda

Consulta la mia agenda

Organi

• Department Council - Department of Oncology

• Consiglio di Dipartimento - Dipartimento di Oncologia